USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PLF4_HUMAN USC-OGP 2-DE database:  PLF4_HUMAN PLF4_HUMAN General information about the entry View entry in simple text format Entry name PLF4_HUMAN Primary accession number P02776 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Platelet factor 4; Short=PF-4; AltName: Full=C-X-C motif chemokine 4; AltName: Full=Iroplact; AltName: Full=Oncostatin-A; Contains: RecName: Full=Platelet factor 4, short form; Flags: Precursor;. Gene name Name=PF4 Synonyms=CXCL4, SCYB4 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1090: pI=8.86; Mw=14010 SPOT OGP-1091: pI=9.10; Mw=13647 Cross-references UniProtKB/Swiss-Prot P02776; PLF4_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PLF4_HUMAN Primary accession number P02776 Secondary accession number(s) Q53X61 Q9UC64 Q9UC65 Sequence was last modified on  July 1, 1989 (version 2) Annotations were last modified on  March 15, 2017 (version 171) Name and origin of the protein Description RecName: Full=Platelet factor 4; Short=PF-4; AltName: Full=C-X-C motif chemokine 4; AltName: Full=Iroplact; AltName: Full=Oncostatin-A; Contains: RecName: Full=Platelet factor 4, short form; Flags: Precursor; Gene name Name=PF4 Synonyms=CXCL4, SCYB4 Encoded on Name=PF4; Synonyms=CXCL4, SCYB4 Keywords 3D-structure; Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing; Disulfide bond; Heparin-binding; Phosphoprotein; Reference proteome; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M25897; AAA60066.1; -; mRNA EMBL AF349466; AAK29643.1; -; Genomic_DNA EMBL CR407677; CAG28605.1; -; mRNA EMBL AC097709; AAY41003.1; -; Genomic_DNA EMBL BC093965; AAH93965.1; -; mRNA EMBL BC112093; AAI12094.1; -; mRNA CCDS CCDS3562.1; -; . PIR A60161; PFHU4; . RefSeq NP_002610.1; NM_002619.3; . UniGene Hs.81564; -; . PDB 1DN3; NMR; -; A=59-73 PDB 1F9Q; X-ray; 2.00 A; A/B/C/D=32-101 PDB 1F9R; X-ray; 2.00 A; A/B/C/D=32-101 PDB 1F9S; X-ray; 2.38 A; A/B/C/D=32-101 PDB 1PFM; NMR; -; A/B/C/D=39-101 PDB 1PFN; NMR; -; A/B/C/D=39-101 PDB 1RHP; X-ray; 2.40 A; A/B/C/D=32-101 PDB 4R9W; X-ray; 2.50 A; A/B=32-101 PDB 4R9Y; X-ray; 4.11 A; A/B/C/D=32-101 PDB 4RAU; X-ray; 3.74 A; C/F/I/L/O/R/U/X=32-101 PDBsum 1DN3; -; . PDBsum 1F9Q; -; . PDBsum 1F9R; -; . PDBsum 1F9S; -; . PDBsum 1PFM; -; . PDBsum 1PFN; -; . PDBsum 1RHP; -; . PDBsum 4R9W; -; . PDBsum 4R9Y; -; . PDBsum 4RAU; -; . ProteinModelPortal P02776; -; . SMR P02776; -; . BioGrid 111219; 7; . DIP DIP-56941N; -; . IntAct P02776; 4; . STRING 9606.ENSP00000296029; -; . BindingDB P02776; -; . ChEMBL CHEMBL3286075; -; . DrugBank DB00055; Drotrecogin alfa; . PhosphoSitePlus P02776; -; . BioMuta PF4; -; . DMDM 130304; -; . OGP P02776; -; . PaxDb P02776; -; . PeptideAtlas P02776; -; . PRIDE P02776; -; . TopDownProteomics P02776; -; . Ensembl ENST00000296029; ENSP00000296029; ENSG00000163737; . GeneID 5196; -; . KEGG hsa:5196; -; . UCSC uc003hhi.4; human; . CTD 5196; -; . DisGeNET 5196; -; . GeneCards PF4; -; . HGNC HGNC:8861; PF4; . HPA CAB026008; -; . HPA HPA052485; -; . MIM 173460; gene; . neXtProt NX_P02776; -; . OpenTargets ENSG00000163737; -; . PharmGKB PA33203; -; . eggNOG ENOG410J314; Eukaryota; . eggNOG ENOG4111556; LUCA; . GeneTree ENSGT00530000062901; -; . HOGENOM HOG000220915; -; . HOVERGEN HBG107789; -; . InParanoid P02776; -; . KO K05407; -; . OMA CAVPQLI; -; . OrthoDB EOG091G14JD; -; . PhylomeDB P02776; -; . TreeFam TF333433; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-140875; Common Pathway of Fibrin Clot Formation; . Reactome R-HSA-202733; Cell surface interactions at the vascular wall; . Reactome R-HSA-380108; Chemokine receptors bind chemokines; . Reactome R-HSA-418594; G alpha (i) signalling events; . EvolutionaryTrace P02776; -; . GeneWiki Platelet_factor_4; -; . GenomeRNAi 5196; -; . PMAP-CutDB P02776; -; . PRO PR:P02776; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000163737; -; . CleanEx HS_PF4; -; . Genevisible P02776; HS; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IBA:GO_Central; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0008009; F:chemokine activity; TAS:UniProtKB; . GO GO:0048248; F:CXCR3 chemokine receptor binding; IDA:UniProtKB; . GO GO:0008201; F:heparin binding; IDA:UniProtKB; . GO GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central; . GO GO:0019221; P:cytokine-mediated signaling pathway; IDA:UniProtKB; . GO GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central; . GO GO:0006955; P:immune response; IBA:GO_Central; . GO GO:0006954; P:inflammatory response; IBA:GO_Central; . GO GO:0030595; P:leukocyte chemotaxis; IDA:UniProtKB; . GO GO:0016525; P:negative regulation of angiogenesis; IDA:UniProtKB; . GO GO:0045918; P:negative regulation of cytolysis; IDA:BHF-UCL; . GO GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:BHF-UCL; . GO GO:0045653; P:negative regulation of megakaryocyte differentiation; IDA:UniProtKB; . GO GO:0045347; P:negative regulation of MHC class II biosynthetic process; IDA:BHF-UCL; . GO GO:0030168; P:platelet activation; IDA:UniProtKB; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0030816; P:positive regulation of cAMP metabolic process; IDA:UniProtKB; . GO GO:0043950; P:positive regulation of cAMP-mediated signaling; IDA:UniProtKB; . GO GO:0010628; P:positive regulation of gene expression; IDA:BHF-UCL; . GO GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IDA:BHF-UCL; . GO GO:0045651; P:positive regulation of macrophage differentiation; IDA:BHF-UCL; . GO GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB; . GO GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL; . GO GO:0042127; P:regulation of cell proliferation; IDA:UniProtKB; . GO GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central; . CDD cd00273; Chemokine_CXC; 1; . InterPro IPR001089; Chemokine_CXC; . InterPro IPR018048; Chemokine_CXC_CS; . InterPro IPR001811; Chemokine_IL8-like_dom; . InterPro IPR033899; CXC_Chemokine_domain; . InterPro IPR027222; PF4; . PANTHER PTHR10179; PTHR10179; 1; . PANTHER PTHR10179:SF53; PTHR10179:SF53; 1; . Pfam PF00048; IL8; 1; . PRINTS PR00437; SMALLCYTKCXC; . SMART SM00199; SCY; 1; . SUPFAM SSF54117; SSF54117; 1; . PROSITE PS00471; SMALL_CYTOKINES_CXC; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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